Views: 1 Author: Site Editor Publish Time: 2022-03-21 Origin: Site
Human growth hormone can also be used by healthy people
Human growth hormone is sometimes used in healthy older men and women.
Growth hormone levels tend to decline with age, and many doctors believe that supplementing younger levels can help slow down some of the damage of aging.
Given its beneficial metabolic effects on muscle mass, strength, energy, cell regeneration and fat reduction, there are many supporters of this use, even though human growth hormone may not particularly delay the aging process.
Please note that in order to prescribe human growth hormone for adult hormone deficiency in the United States, the patient must have a confirmed history of pituitary disease or GH deficiency in children.
Under federal law, it is illegal to prescribe growth hormone for any off label use, including anti-aging and fitness purposes.
Growth hormone can be given by subcutaneous or intramuscular injection.
Clinical study of human growth hormone
During the clinical study, the pharmacokinetic characteristics of growth hormone after two methods of use were determined.
When administered subcutaneously, growth hormone had similar but moderate levels of bioavailability (75% versus 63%).
The drug metabolism rate after the two routes is also very similar.
The half-life of human growth hormone after subcutaneous and intramuscular injection is about 3.8 hours and 4.9 hours respectively.
Baseline hormone levels are usually reached from 12 to 18 hours after injection, and the time of intramuscular injection is slower.
However, considering the delayed rise of IGF-1 level, human growth hormone can remain elevated 24 hours after injection, and the metabolic activity of human growth hormone will exceed its actual level in the body.
Although drug absorption is acceptable for both methods of use, daily subcutaneous administration is generally considered the preferred method for the use of growth hormone.
Specific analysis of growth hormone activity shows that hormones with multiple effects.
It is the anabolism of skeletal muscle and shows an increase in the size and number of cells (called hypertrophy and proliferation, respectively).
Human growth hormone has a positive effect on body organs
This hormone seems to promote growth in all organs of the body, excluding the eyes and brain.
Human growth hormone has a diabetes effect on carbohydrate metabolism, which means it leads to elevated blood sugar levels (usually associated with diabetes).
Over time administration of growth hormone may induce type 2 (insulin resistance) diabetes.
This hormone also supports the hydrolysis of triglycerides in adipose tissue and reduces fat storage in the body. Consistent with this is often the reduction of serum cholesterol.
The drug also reduces the content of potassium, phosphorus and sodium, which may lead to a decrease in the level of thyroid hormone triiodothyronine (T3).
The latter effect marks a decrease in the metabolism of thyroid support and may interfere with the effectiveness of growth hormone prolongation therapy.
Human growth hormone has direct and indirect effects. On the direct side, hGH proteins attach to receptors in muscle, bone and adipose tissue and send information to support anabolism and lipolysis (fat reduction).
Growth hormone also directly increases glucose synthesis (gluconeogenesis) in the liver and induces insulin resistance by blocking its activity in target cells.
The indirect effect of growth hormone is mainly mediated by IGF-1 (insulin-like growth factor), which is produced in response to growth hormone in the liver and almost all other tissues.
IGF-1 is also anabolic to muscle and bone, increasing the activity of growth hormone. However, IGF-1 also has a strong antagonistic effect against growth hormone.
This includes increased fat production (fat retention), increased glucose consumption and reduced gluconeogenesis.
The synergistic and antagonistic effects of the two hormones combine to form the characteristics of human growth hormone.
Similarly, they also determine the effects of growth hormone administration, including supporting lipolysis, elevated blood glucose levels and reduced insulin sensitivity.
human growth hormone is controversial
Growth hormone is considered as a controversial anabolic and performance enhancing drug in the field of bodybuilding and sports.
The main issue at issue is the exact extent of the potential benefits of this substance.
Although studies of HIV + patients in a lean state tend to support potentially strong anabolic and antimetabolic properties, there is a lack of studies demonstrating these same effects in healthy adults and athletes.
In the 1980s, a large number of myths revolved around the discussion of hGH in the fitness industry, which may be driven by the high cost of drugs and their name ("growth hormone").
It was once considered the most powerful anabolic substance you can buy. Today, recombinant human growth hormone is more readily available and readily available.
Now, most experienced people tend to think that the characteristic of growth hormone promoting fat loss is the most obvious.
The drug can support muscle growth, increase strength and increase exercise performance, but its effect is usually milder than that of anabolic / androgen steroids.
However, for a very advanced athlete or bodybuilder, growth hormone can be more helpful to promote body and performance than steroids alone.