Views: 1 Author: Site Editor Publish Time: 2022-02-23 Origin: Site
Human growth hormone is originally a substance secreted by human pituitary gland. The "development history" refers to its discovery, application and the development process of reversing aging.
Discovery of human auxin
Scientists first discovered that the human pituitary gland secretes human auxin hGH in the 1920s, but it has not been applied in medical practice until 1958, an endocrinologist in Boston found that a child with stunted growth (dwarfism) does not secrete human auxin, He tried to inject the substance into his body, and the child began to grow.
This has led to the treatment of many teenagers who lack human auxin and are stunted.
The reason for juvenile dwarfism is that their pituitary gland is ill or defective, and their function of secreting auxin is basically or completely lost.
Their body not only grows slowly or stops growing, making them look like a little old man, but also their IQ value is much lower than that of normal children.
After auxin is supplemented, It is equivalent to that their pituitary gland began to secrete auxin again, began to grow their body again, and their academic performance also improved.
The primary stage of human auxin acquisition
At that time, the only source of human auxin used to treat these dwarfs was obtained from the brains of dead people.
Only a few drops can be extracted from thousands of brains for the treatment of children and adolescents.
Since heating will destroy the structure of human auxin, Pasteur sterilization is used for disinfection. It can be imagined how expensive human auxin was at that time.
But in the 1980s, a terrible disease caused the U.S. Food and Drug Administration FDA to stop the production and sale of the drug extracted from the brains of the dead.
The disease, known as Creutzfeldt Jakob disease and mad cow disease in the UK, is characterized by progressive dementia, muscle loss of control and usually death within five years of onset.
Obtaining synthetic human auxin
After losing its source, human auxin must be obtained by synthetic method from scratch.
This is a very arduous task. Human auxin is a macromolecular protein. It is the largest protein secreted by the pituitary gland and is composed of 191 amino acid molecules.
It is a very detailed and difficult work to link so many amino acid molecules into a macromolecule according to a certain structure. Which one is in what position and how to link.
The 1980s was a favorable period for the development of this drug in the United States.
In 1985, the US Congress passed a bill to financially encourage the development and production of drugs to treat some rare diseases of less than 200000 patients.
Moreover, in the 1980s, genetic engineering technology has begun to mature.
Gene splicing technology enables scientists to "clone" the proteins that make up the human body, that is, they can clearly distinguish the arrangement order of DNA of specific proteins.
Once this specific protein is cloned, its mass production can be completed.
Massive access to human auxin
One of the inventors of genetic engineering, Nobel laureate Boyer and his assistants cloned the human insulin gene for the first time.
In 1985, they obtained human auxin, a drug produced by DNA gene recombination technology for the second time in human history.
Its biological activity is exactly the same as that of human auxin secreted by human body, but there is still an amino acid difference in structure.
Later, another large pharmaceutical company cooperated with the University of California to successfully synthesize human auxin composed of 191 amino acids, which is 100% consistent with the human auxin secreted by the human brain in physical structure, chemistry and biology.
However, the real potential of human auxin lies at the other end of life - the middle-aged and elderly. This is the successful application in the field of anti-aging since the 1990s.
Dr Rudman's great achievements
Dr. Rudman is a pioneer in studying the anti-aging effect of human auxin. In 1985, he first pointed out in the American Journal of Geriatric Society that human auxin can reverse aging.
In the subsequent clinical comparative study, he came to a surprising conclusion, which was published in the authoritative and conservative New England Journal of medicine.
He pointed out that the degree of reversing human aging in the supplementary treatment of human auxin for half a year is equivalent to 10 to 20 years!
In other words, after half a year of human auxin treatment, those elderly people are 10 to 20 years younger in varying degrees. What a breakthrough!
Dr Rudman's pioneering role has inspired doctors and scientists around the world to devote themselves to the research of human auxin on aging and aging related diseases.
Dr. Kratz wrote "making people young hGH" after studying their 28000 papers and visiting scientists and doctors in the United States, Britain, Denmark and Sweden and thousands of their patients. Dr. Kratz said that Dr. Rudman proved that aging is neither inevitable nor irreversible.