Views:8 Author:Site Editor Publish Time: 2021-09-13 Origin:Site
Growth hormone is a peptide hormone. It stores water and has no hepatotoxicity. It can strengthen protein synthesis and promote lipolysis. It can promote cell proliferation. It can repair damaged cartilage, tendons and joints, enhance libido and increase metabolism. . Suitable for muscle gain and use during fat loss.
Strength increase: ★ ★
Muscle gain: ★ ★ ★
Reduce fat/moisture: ★ ★ ★ ★
Side effects: ★
Effect retention: ★ ★ ★ ★
Specification: 10IU*10 bottles/box
Cycle: from 3 to 6 months
Growth hormone (genetically recombined growth hormone)
Recombinant growth hormone is a synthetic human growth hormone (HGH). It is actually a variant of the endogenous hGH protein, which contains the same 191 amino acid sequence as human growth hormone, but contains an additional amino acid, methionine. For this reason, genetically recombinant growth hormone is usually described as recombinant human growth hormone. As a growth hormone drug, genetically recombinant growth hormone supports the growth of bone, skeletal muscle, connective tissue and internal organs. It also plays a role in protein, carbohydrate, lipid and mineral metabolism. In medical treatment, genetic recombinant growth hormone is used to treat endogenous growth disorders caused by growth hormone deficiency in children. When used as a long-term treatment to stop linear growth after the epiphysis is closed, this drug may have a significant positive effect on linear growth. Recombinant growth hormone is considered to be therapeutically equivalent to growth hormone produced by the pituitary gland. As a human growth hormone (HGH) drug, genetically recombinant growth hormone is highly valued by bodybuilders and athletes because it can promote the loss of fat and the growth of muscle and connective tissue.
Although genetically recombinant growth hormone is considered to be equivalent to human growth hormone, it is not a natural protein of the human body. This may increase the chance of producing growth hormone antibodies during treatment. Antibodies work by binding to growth hormone molecules, thereby affecting their ability to exert activity. In a clinical investigation, two-thirds (2/3) of children treated with genetically recombinant growth hormone developed growth hormone antibodies a year later. In a similar survey on growth hormone management, only 1 out of 7 patients developed growth hormone serum antibodies. It is worth noting that in these two studies, the antibody response was not strong, and it did not seem to have the ability to significantly reduce the effect of drug treatment. The reduction effect (determined by antibody levels) appears in a very small percentage (less than 1%) of patients. Despite this, however, the original growth hormone with 191 amino acids is considered more worthwhile.
1: Scientists knew about the existence of human growth hormone as early as 1920,
2: But it was not used for clinical treatment until 1958.
3: On July 5, 1990, Daniel of human growth hormone in men over 60 years old (the application of human growth hormone in men over 60 years old) of the Medical College of Wisconsin, USA, this paper can be said to be HGH applied to anti-aging Research a milestone in the history of medicine.
4: In 1996, the U.S. FDA (U.S. Food and Drug Administration) finally officially approved the clinical use of HGH to treat all patients lacking HGH, including normal adults.
HGH human growth hormone fundamentally solves the human anti-aging problem (from American literature):
Scientists have discovered that the amount of HGH human growth hormone secreted tends to decrease with age. The decrease is about 15% between 12 and 30 years old, and less than half of the original rate before the age of 60. The daily secretion of growth hormone reaches a peak of about 500 micrograms for 20-year-olds, only 300 micrograms by 60 years old, and only 25 micrograms for 80-year-olds. It is generally believed that after 30 years of age is the beginning of aging, growth hormone attenuates with age, so supplementing growth hormone is the key to enhancing the function of the immune system and achieving longevity. Dr. Rodman of the University of Wisconson School of Medicine in the United States pointed out that human aging is actually caused by the lack of growth hormone. As long as growth hormone is used to stimulate and activate the pituitary gland, it can restore the function of secreting and releasing growth hormone. There will be a phenomenon of rejuvenation. The world-renowned anti-aging medical expert and Dean of the American Academy of Anti-Aging Medical Sciences, Dr. Karaz, pointed out that HGH human growth hormone is the world's first (and so far the only one) substance that can reverse aging. It can delay, stop, Even reverse aging. In August 1996, the US FDA approved the long-term use of HGH human growth hormone for adults. The number of people using growth hormone (produced and sold as food in the US) has increased rapidly since the end of 1998. According to statistics at the end of 1999, millions of people in the US have used it.
Recombinant growth hormone was approved for sale in the United States in 1985. This is the world's first synthetic growth hormone drug, produced through a manufacturing process called inclusion body technology. This technology inserts the DNA encoded by the human growth hormone gene into E. coli bacteria to assemble and synthesize pure protein. Before the advent of synthetic growth hormone, human growth hormone could only be made into medicine by extracting natural proteins from human corpses. In 1985, due to a rare neurological disease epidemic among patients, the use of biological or cadaveric growth hormone was banned in the United States. Recombinant growth hormone was approved for sale in the same year, allowing Genentech to monopolize the growth hormone market in the short term.
Growth hormone is usually contained in a vial of white lyophilized powder, which needs to be reconstituted with sterile or bacteriostatic water before use. The dosage of each vial ranges from 8 to 15 iu.
Recombinant growth hormone is a polypeptide (methionyl human growth hormone) produced by recombinant DNA technology. It has 191 amino acid residues and a molecular weight of 22,256.
To refrigerate, it needs to be refrigerated (2-8 degrees) before and after reformulation.
Side effects (general):
The most frequently reported adverse reactions related to genetic recombinant growth hormone therapy include: carpal tunnel syndrome, mole growth (nevi and birthmark), gynecomastia and pancreatitis. It should be noted that the side effects of recombinant growth hormone are usually similar to those of growth hormone therapy. The abuse of genetically modified growth hormone can lead to diabetes, acromegaly (thickening of bones, most notably the feet, forehead, hands, jaw, and elbow), and the enlargement of internal organs. Due to the growth-promoting effect of human growth hormone, the drug should not be used by individuals with active or recurrent cancer.
Side effects (impaired glucose tolerance):
Recombinant growth hormone can reduce the body's sensitivity to insulin, thereby increasing blood sugar levels. This may occur in individuals without diabetes or glucose intolerance.
Side effects (injection site):
Subcutaneous injection of genetically recombinant growth hormone may cause redness, itching or lumps at the injection site. It may also cause a local reduction of adipose tissue, which may also be caused by repeated injections at the same site.
Recombinant growth hormone is administered by subcutaneous injection. 1 mg of recombinant growth hormone is approximately equivalent to 3 international units (3IU). When used to treat children with growth disorders due to growth hormone deficiency, a dose of 0.04 mg per kilogram of body weight is administered daily. For a person weighing about 180 pounds, this is equivalent to about 10 IU (International Units) per day. Over time, after assessing the patient's IGF-1 level and clinical response, the long-term maintenance dose may be much lower than 10IU (International Unit).
Bodybuilders usually start with 3-4IU as the starting dose, and it is safe to do so within 8IU per day. Top bodybuilding sports also have more than 10IU.