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Droasterone was first introduced in 1959, and Xingtec also developed the other well-known steroid "Anadrol". But drostanolone was only available as a prescription drug about a decade after its introduction. Eli Lilly and Xingtaike have reached an agreement whereby the two parties will share a certain amount of research and development costs in exchange for the right to market research results. So in the U.S. market, Eli Lilly is sold under the name drostanolone, while other markets are owned by Xingtec. Below is a list of products including drostanolone that are licensed for sale in other countries: Sarva-Syntex in Belgium, Cilag in Portugal, Masteril in the UK and Bulgaria, and Metormon in Spain. Drostanolone propionate is also popular in more places under the names: Permastril (Cassenne, France), Mastisol (Shinogi, Japan), and Masterid (Granter, Germany).


The U.S. Food and Drug Administration approved drostanolone for the treatment of postmenopausal women with advanced breast cancer, which is also the FDA's clinical guidance for drostanolone on the international market. Relevant research literature also reminds doctors and female patients that the virilization reaction of patients taking drostanolone at the same dose is less than that of taking testosterone propionate. So drostanolone is a more reliable alternative to testosterone injections. However, the injection volume of 300 mg/week is relatively high. The instructions also reminded us that mild virilization such as voice, worsening of acne, facial hair growth and clitoral hypertrophy were common after taking the drug. There are also research reports showing that if long-term treatment of virilizing characteristics will be more significant.


In the 1970s and 1980s, drostanolone enjoyed a great reputation among athletes. It's just that the good times didn't last long, and manufacturers began to stop selling this drug as an agent. It may be due to the emergence of more effective treatments for breast cancer and the slow decline in steroid prescriptions at this stage. The first to be ready to leave the market was drostanolone propionate in the United States, which was withdrawn around the 1980s. Then France and Spain also lost market share. In Western countries, drostanolone last disappeared in the late 1990s. However, drostasterone is still sold in Pharmacopias in the United States, and there are no legal restrictions on the market, but it seems unlikely that it will reappear as a prescription drug product.


Specifications available:


Drostasterone enanthate is typically stored in oils at 200 mg/mll strength.




Structural features:


Droasterone is a modified form of DHT. It exhibits different properties by introducing a methyl group at carbon-2(α), which significantly increases steroid anabolism by enhancing its resistance to 3-hydroxysteroid dehydrogenase in skeletal muscle tissue strength. where the heptanoate has been attached to the 17-beta hydroxyl group. Esterified steroids are less polar than free steroids and are absorbed more slowly from the injection area. Once in the blood, the ester is removed to produce free (active) droxidol. Esterified steroids are designed to prolong the therapeutic effect after administration, allowing less frequent injections than injections of free (unesterified) steroids. The half-life of drostanolone enanthate is approximately 10.5 days after injection.




Side Effects (estrogen):


Droasterone is not aromatized by the body and has no measured estrogenicity. Anti-androgens are unnecessary when using this steroid, so drostanolone can make you look leaner,




Side effects (androgens):


Droasterone, although classified as an anabolic steroid, may still have androgenic side effects, especially when used at higher than normal therapeutic doses. This can include a range of side effects: oily skin, body/facial hair growth. Anabolic/androgenic steroids may also exacerbate male pattern baldness.




Female users should be reminded that the possible reactions are: menstrual irregularities, changes in skin texture, facial hair growth, and clitoral hypertrophy. Droasterone is a steroid with relatively low androgenic activity relative to its tissue-building effects, making it a rather high threshold for side effects compared to androgenic drugs such as testosterone, methyltestosterone, or fluoxymesterone. Note that drostasterone is not affected by 5-alpha reductase, so it is not affected by concomitant use of finasteride or dutasteride.




Side effects (hepatotoxicity):


Droasterone is not hepatotoxic, so hepatotoxicity is unlikely.




Side Effects (Cardiovascular):


Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to lower HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift HDL to LDL balance, leading to a greater risk of arteriosclerosis. The relative effects of anabolic/androgenic steroids on serum lipids depend on dose, route of administration (oral vs. injection), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Due to its non-aromatizable nature, Drostanolone has a stronger negative effect on the liver treatment of cholesterol than testosterone or nandrolone, but less so than c-17alpha alkylating steroids. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and cause left ventricular hypertrophy.




To help reduce cardiovascular stress, supplementation with fish oil (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or products with similar ingredients is recommended.




Side Effects (Testosterone Suppression):




Suppresses endogenous testosterone production. Use requires PCT.


Treatment (Male):


Drostasterone Enanthate For physique or performance enhancement purposes, the drug is usually dosed at 200-400 mg per week for 10-16 weeks of acclimation. This level of use is sufficient to provide measurable gains in lean muscle mass and strength.


Droasterone is often combined with other steroids for enhanced effects. Common stacks include injectable anabolites like Deca-Durabolin (nandrolone decanoate) or Equipoise (boldenone), which can provide significantly stronger muscle without excessive water retention. For mass gain, it is often combined with injectable testosterone. These combinations can build solid muscle with lower water storage levels and estrogenic side effects than using these steroids alone (usually at higher doses). However, drostanolone propionate is most commonly used in the cutting phase of training. In this case, it is often combined with other non-aromatizable steroids such as Winstrol, Primobolan, Parabolan or Anavar to greatly aid in muscle retention and fat loss.




Treatment (women):




Prescribing guidelines for drostanolone recommend three times a week for a total dose of 100 mg. Administer treatment for at least 8 to 12 weeks before evaluating efficacy. If successful, the drug can be continued as long as satisfactory results are obtained. Note that at recommended doses, viral symptoms are common. When used for strength or performance enhancement purposes, a dose of 50 mg per week is most common for 4 to 6 weeks. Virilization at doses of 100 mg or less per week



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