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What is the role of Human growth hormone

Views: 1     Author: Site Editor     Publish Time: 2022-04-24      Origin: Site

Human growth hormone (hGH) is a 191 amino acid peptide hormone secreted by growth hormone (GH)-secreting cells in the anterior pituitary gland containing eosinophilic granules.

This product is recombinant human growth hormone (rhGH) produced by recombinant Escherichia coli secretory expression technology, and its amino acid content and sequence are exactly the same as human growth hormone. This product is synthesized in Escherichia coli (E.Coli). Synthesis is by prehormone.

characteristic

This prohormone consists of growth hormone that is naturally present in bacteria, linked to a signal peptide. The prohormone splits in the bacterial cell lining, releasing an end product identical to natural growth hormone into the parietal space, and then only destroys the outer cell wall for collection, while the inner cell wall remains intact to ensure that little bacterial protein contaminates the final product.

Physiological effect

Secreted gene recombinant human growth hormone (rhGH) has the same effect as human endogenous growth hormone, stimulates the differentiation and proliferation of epiphyseal chondrocytes, stimulates the growth of cartilage stromal cells, stimulates the differentiation and proliferation of osteoblasts, and causes linear growth acceleration and bone growth.

Promote whole body protein synthesis, correct negative nitrogen balance after surgery and other trauma, correct hypoproteinemia caused by severe infection and liver cirrhosis; stimulate immune globulin synthesis, stimulate the proliferation of lymphoid tissue, macrophages and lymphocytes , enhance anti-infection ability;

Stimulates collagen cells in burn wounds and surgical incisions to synthesize fibroblasts, macrophages divide and proliferate, accelerate wound healing, promote myocardial protein synthesis, increase myocardial contractility, reduce myocardial oxygen consumption, regulate fat metabolism, and reduce serum cholesterol and low-density lipids Protein level; supplement growth hormone deficiency or deficiency, regulate fat metabolism, bone metabolism, heart and kidney function in adults.

Serum hGH concentrations indicate sporadic or paroxysmal changes in hGH secretion over a 24-hour period as well as significant changes in hGH secretion associated with physiological and sleep-related changes.

In addition, numerous environmental and metabolic factors including (but not limited to) nutritional intake, exercise, physiological stress and exercise, depression, trauma and age all affect the secretion and clearance of hGH and thus its concentration in serum.

Basic serum hGH levels cannot be detected by conventional RIA or IRMA immunoassays.

The ultrasensitive hGH assay has a sensitivity of 0.005 ng/mL and is capable of discriminating previously undetectable differences between populations.

Measurement of hGH hypersensitivity is helpful in studying the growth hormone axis.

Due to the low levels and pulsatile secretion of hGH, provocation testing is the most common method to test for hGH deficiency.

Provocation tests stimulate pituitary growth hormone to secrete hGH in response to pharmacological stimuli.

Insulin, clonidine, arginine, levodopa, hormone-releasing growth hormone, and propranolol have all been used to stimulate hGH release. None of them maximized hGH release, indicating a lack of hGH. Excessive growth hormone can be tested for excess growth hormone in individuals with elevated hGH (see Acromegaly).

Inhibition tests measure changes in hGH levels by creating a glucose-containing hyperglycemic state.

An inability to suppress hGH with hyperglycemia indicates excess hormone. Human growth hormone assays are used in the diagnosis and treatment of disorders of the anterior pituitary gland.

Human growth hormone can promote the growth of bones, internal organs and the whole body, promote protein synthesis, influence fat and mineral metabolism, and play a very important role in human growth and development.

Human growth hormone is commonly used clinically to treat growth disorders caused by insufficient endogenous growth hormone secretion, such as dwarfism and short stature.

Of course, it is also clinically used to treat some burns, fractures, trauma, bleeding ulcers, muscle atrophy, osteoporosis and other diseases.

The application of Human growth hormone has strict indications and contraindications. It needs to be fully evaluated before using it.

It is necessary to do endocrine-related Human growth hormone and evaluation of adrenal cortex function, liver function, thyroid function and bone age, and some even need to do brain Pituitary MRI to strictly evaluate indications and screen out contraindications in a timely manner.


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